Acide cichorique

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Nom de la substance

Acide cichorique

Famille moléculaire

Source végétale

Propriétés

  • Activité antioxydante de l’acide cichorique dans un modèle d’émulsion lipidique peroxydante, potentialisée par les alkylamides d’Echinacea purpurea, bien que ceux-ci ne présentent cette activité [2]
  • Hépatoprotecteur [3]
  • Diminue l'insulino-résistance [4], améliore la résistance à l'insuline et les lésions hépatiques dans le diabète, en régulant l'homéostasie hépatique du glucose et la réponse antioxydante [5], pourrait prévenir les complications du diabète [6]
  • Anti-inflammatoire et immunomodulant [7]
  • Stimule la phagocytose
  • Inhibe l'activité de l'enzyme hyaluronidase
  • Antiviral, anti-hépatite B [8], inhibiteur du HIV [9], [10]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. ↑ Wang Hong, Liu Wen-Zhi, Lu Xiao-Lei, Chen Shi-Zhong, Ai Tie-Min. Determination of cichoric acid in Echinacea purpurea. Zhongguo zhongyao zazhi, 2002, vol. 27, no6, pp. 418-420
  2. ↑ Line Thygesen, Johanna Thulin, Alan Mortensen, Leif H. Skibsted, Per Molgaard. Antioxidant activity of cichoric acid and alkamides from Echinacea purpurea, alone and in combination. Food Chemistry, Volume 101, Issue 1, 2007, Pages 74-81, https://doi.org/10.1016/j.foodchem.2005.11.048.
  3. ↑ Ma, J., Li, M., Kalavagunta, P. K., Li, J., He, Q., Zhang, Y., ... & Shang, J. (2018). Protective effects of cichoric acid on H2O2-induced oxidative injury in hepatocytes and larval zebrafish models. Biomedicine & Pharmacotherapy, 104, 679-685.
  4. ↑ Zhu, D., Wang, Y., Du, Q., Liu, Z., & Liu, X. (2015). Cichoric acid reverses insulin resistance and suppresses inflammatory responses in the glucosamine-induced HepG2 cells. Journal of agricultural and food chemistry, 63(51), 10903-10913.
  5. ↑ Zhu, D., Zhang, N., Zhou, X., Zhang, M., Liu, Z., & Liu, X. (2017). Cichoric acid regulates the hepatic glucose homeostasis via AMPK pathway and activates the antioxidant response in high glucose-induced hepatocyte injury. RSC advances, 7(3), 1363-1375.
  6. ↑ Di Zhu, Xinglin Zhang, Yajie Niu, Zhijun Diao, Bo Ren, Xingyu Li, Zhigang Liu, Xuebo Liu. Cichoric acid improved hyperglycaemia and restored muscle injury via activating antioxidant response in MLD-STZ-induced diabetic mice. Food and Chemical Toxicology, Volume 107, Part A, 2017, Pages 138-149, https://doi.org/10.1016/j.fct.2017.06.041.
  7. ↑ Xue CH, A SX, Wang MJ, Wu Q, Liu JH, Zhang LF, Wu Y, Wu H, Chai ST. Echinacea Purpurea Extract (cichoric Acid) Exerts an Anti-inflammatory Effect on Yak PBMCs and Regulates the TLR4 Signalling Pathway. J Vet Res. 2021 Mar 9;65(1):109-115. doi: 10.2478/jvetres-2021-0016. PMID 33817403; PMCID: PMC8009576.
  8. ↑ Zhang, H. L., Dai, L. H., Wu, Y. H., Yu, X. P., Zhang, Y. Y., Guan, R. F., ... & Zhao, J. (2014). Evaluation of hepatocyteprotective and anti-hepatitis B virus properties of Cichoric acid from Cichorium intybus leaves in cell culture. Biological and Pharmaceutical Bulletin, b14-00137.
  9. ↑ Lin Z, Neamati N, Zhao H, Kiryu Y, Turpin JA, Aberham C, Strebel K, Kohn K, Witvrouw M, Pannecouque C, Debyser Z, De Clercq E, Rice WG, Pommier Y, Burke TR Jr. Chicoric acid analogues as HIV-1 integrase inhibitors. J Med Chem. 1999 Apr 22;42(8):1401-14. PMID 10212126
  10. ↑ King PJ, Ma G, Miao W, Jia Q, McDougall BR, Reinecke MG, Cornell C, Kuan J, Kim TR, Robinson WE Jr. Structure-activity relationships: analogues of the dicaffeoylquinic and dicaffeoyltartaric acids as potent inhibitors of human immunodeficiency virus type 1 integrase and replication. J Med Chem. 1999 Feb 11;42(3):497-509. PMID 9986720
  11. ↑ Bauer R. Standardization of Echinacea purpurea expressed juice with reference to cichoric acid and alkamides. Journal of herbs, spices & medicinal plants, 1999, vol. 6, no3, pp. 51-62
  • Chantal Bergeron, Stefan Gafner, Laura L. Batcha, Cindy K. Angerhofer. Stabilization of Caffeic Acid Derivatives in Echinacea purpurea L. Glycerin Extract. Journal of Agricultural and Food Chemistry, 2002, 50 (14), pp 3967–3970
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