Flavonolignane

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Nom de la substance

Flavonolignane

Famille moléculaire

Source végétale

Propriétés

  • Inhibiteur des pompes d'efflux bactériennes [1], [2]
  • Hépatoprotecteur
  • La silymarine présente des effets immunosuppresseurs [3], [4], [5]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. Stermitz FR, Tawara-Matsuda J, Lorenz P, Mueller P, Zenewicz L, Lewis K. 5'-Methoxyhydnocarpin-D and pheophorbide A: Berberis species components that potentiate berberine growth inhibition of resistant Staphylococcus aureus. J Nat Prod. 2000 Aug;63(8):1146-9. PMID 10978214
  2. Stermitz FR, Lorenz P, Tawara JN, Zenewicz LA, Lewis K. Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1433-7. PMID 10677479
  3. Gharagozloo, M., Javid, E. N., Rezaei, A., & Mousavizadeh, K. (2013). Silymarin inhibits cell cycle progression and mTOR activity in activated human T cells: therapeutic implications for autoimmune diseases. Basic & clinical pharmacology & toxicology, 112(4), 251–256. https://doi.org/10.1111/bcpt.12032 PMID 23121838
  4. Esmaeil N, Anaraki SB, Gharagozloo M, Moayedi B. Silymarin impacts on immune system as an immunomodulator: One key for many locks. Int Immunopharmacol. 2017 Sep;50:194-201. doi: 10.1016/j.intimp.2017.06.030. PMID 28672215
  5. Gharagozloo M, Jafari S, Esmaeil N, Javid EN, Bagherpour B, Rezaei A. Immunosuppressive effect of silymarin on mitogen-activated protein kinase signalling pathway: the impact on T cell proliferation and cytokine production. Basic Clin Pharmacol Toxicol. 2013 Sep;113(3):209-14. doi: 10.1111/bcpt.12088. PMID 23701595