Myrcène

De WikiPhyto

Nom de la substance

Myrcène, béta-myrcène

Famille moléculaire

Hydrocarbure monoterpénique

Source végétale

Propriétés

  • Sédatif et relaxant musculaire [1]
  • Anti-inflammatoire, inhibition de l'interféron gamma et de la production d'IL-4 [2]
  • Puissamment anti-ulcéreux gastrique et duodénal [3]
  • Antalgique [4], diminue la sensibilité à la douleur par augmentation des morphinopeptides endogènes
  • Synergie anti-infectieuse avec géranial et néral [5]

Effet thérapeutique

Effets indésirables

  • Toxicité par voie intrapéritonéale [6]
  • Pas de mutagénicité au test d'Ames [7]
  • Pas de génotoxicité [8]
  • Induction du cytochrome P-450 (sous-famille 2B : CYP4502B1) [9], [10], [11]

Bibliographie

  1. T Gurgel do Vale, E Couto Furtado, JG Santos Jr, GSB Viana. Central effects of citral, myrcene and limonene, constituents of essential oil chemotypes from Lippia alba (Mill.) N.E. Brown. Phytomedicine, Volume 9, Issue 8, 2002, Pages 709-714 [1]
  2. Souza MC, Siani AC, Ramos MF, Menezes-de-Lima OJ, Henriques MG. Evaluation of anti-inflammatory activity of essential oils from two Asteraceae species. Pharmazie. 2003 Aug;58(8):582-6. PMID 12967039
  3. Bonamin F, Moraes TM, Dos Santos RC, Kushima H, Faria FM, Silva MA, Junior IV, Nogueira L, Bauab TM, Souza Brito AR, da Rocha LR, Hiruma-Lima CA. The effect of a minor constituent of essential oil from Citrus aurantium: the role of β-myrcene in preventing peptic ulcer disease. Chem Biol Interact. 2014 Apr 5;212:11-9. doi: 10.1016/j.cbi.2014.01.009. PMID 24480520
  4. Rao VS, Menezes AM, Viana GS. Effect of myrcene on nociception in mice. J Pharm Pharmacol. 1990 Dec;42(12):877-8. PMID 1983154
  5. Onawunmi GO, Yisak WA, Ogunlana EO. Antibacterial constituents in the essential oil of Cymbopogon citratus (DC.) Stapf. J Ethnopharmacol. 1984 Dec;12(3):279-86. PMID 6442749
  6. Paumgartten F. J. R., Delgado I. F., Alves E. N., Nogueira A. C. M. A., De-Farias R. C., Neubert D. Single dose toxicity study of β-myrcene, a natural analgesic substance. Brazilian journal of medical and biological research, Federação de sociedades de biologia experimental. Annual meeting, 1990, vol. 23, no9, pp. 873-877
  7. M.R. Gomes-Carneiro, Márcia E.S. Viana, Israel Felzenszwalb, Francisco J.R. Paumgartten. Evaluation of β-myrcene, α-terpinene and (+)- and (−)-α-pinene in the Salmonella/microsome assay. Food and Chemical Toxicology, Volume 43, Issue 2, February 2005, Pages 247-252 [2]
  8. Zamith HP, Vidal MN, Speit G, Paumgartten FJ. Absence of genotoxic activity of beta-myrcene in the in vivo cytogenetic bone marrow assay. Braz J Med Biol Res. 1993;26(1):93-8. PMID 8220273
  9. Freitas J. C. B. R., Presgrave O. A. F., Fingola F. F., Menezes M. A. C., Paumgartten F. J. R. Effect of β-myrcene on pentobarbital sleeping time. Brazilian journal of medical and biological research, 1993, vol. 26, no5, pp. 519-523. PMID 8257941
  10. De-Oliveira AC, Ribeiro-Pinto LF, Otto SS, Gonçalves A, Paumgartten FJ. Induction of liver monooxygenases by beta-myrcene. Toxicology. 1997 Dec 26;124(2):135-40. PMID 9458003
  11. De-Oliveira AC, Ribeiro-Pinto LF, Paumgartten JR. In vitro inhibition of CYP2B1 monooxygenase by beta-myrcene and other monoterpenoid compounds. Toxicol Lett. 1997 Jun 16;92(1):39-46. PMID 9242356