Ptérostilbène

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Nom de la substance

Ptérostilbène, trans-3,5-diméthoxy-4-hydroxystilbène

Famille moléculaire

Stilbène (polyphénol) proche du resvératrol

Source végétale

Propriétés

  • Puissantes capacités antioxydantes par activation du facteur de transcription Nrf2 capable de déclencher une réponse adaptative qui augmente la réponse antioxydante endogène [2]
  • Anti-inflammatoire, inhibe la signalisation par Nf-kB, diminue la production de facteurs pro-inflammatoires (TNF-alpha, IL-1, IL-6, IL-18, PGE2, COX-1 et COX-2) [3], [4]
  • Neuroprotecteur [5], [6], diminue les effets du processus ischémie-reperfusion chez le rat [7], [8]
  • Antidiabétique [9], antistéatosique [10], [11]
  • Diminue la prise de poids de rats soumis à un régime obésogène [12]
  • Potentialités anticancéreuses [13], [14], [15], [16]
  • Anti-vieillissement [17]

Effet thérapeutique

  • Amélioration du déclin cognitif, des maladies neurodégénératives, du diabète, des maladies cardiovasculaires, du cancer
  • Obésité

Effets indésirables

Bibliographie

  1. ↑ Duarte, N., Ramalhete, C., Rijo, P., Reis, M. A., & Ferreira, M. J. U. (2019). Stilbenoids in Grapes and Wine. Handbook of Dietary Phytochemicals, 1-28.
  2. ↑ Yang, Y., Fan, C., Wang, B., Ma, Z., Wang, D., Gong, B., ... & Luo, E. (2017). Pterostilbene attenuates high glucose-induced oxidative injury in hippocampal neuronal cells by activating nuclear factor erythroid 2-related factor 2. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1863(4), 827-837.
  3. ↑ Hininger-Favier Isabelle. Le ptérostilbène: un antioxydant de nouvelle génération allié dans la lutte contre les effets du vieillissement. Phytothérapie Européenne, n° 120, jan/fév 2021
  4. ↑ Dvorakova, M., & Landa, P. (2017). Anti-inflammatory activity of natural stilbenoids: A review. Pharmacological Research, 124, 126-145.
  5. ↑ La Spina, M., Sansevero, G., Biasutto, L., Zoratti, M., Peruzzo, R., Berardi, N., ... & Azzolini, M. (2019). Pterostilbene Improves Cognitive Performance in Aged Rats: An in Vivo Study. Cell Physiol. Biochem, 52, 232-239.
  6. ↑ Wang, B., Liu, H., Yue, L., Li, X., Zhao, L., Yang, X., ... & Qu, Y. (2016). Neuroprotective effects of pterostilbene against oxidative stress injury: Involvement of nuclear factor erythroid 2-related factor 2 pathway. Brain research, 1643, 70-79.
  7. ↑ Zhou, Y., Zhang, X. M., Ma, A., Zhang, Y. L., Chen, Y. Y., Zhou, H., ... & Jin, X. (2015). Orally administrated pterostilbene attenuates acute cerebral ischemia–reperfusion injury in a dose-and time-dependent manner in mice. Pharmacology Biochemistry and Behavior, 135, 199-209.
  8. ↑ Liu, J., Xu, J., Mi, Y., Yang, Y., Li, Q., Zhou, D., ... & Hou, Y. (2020). Pterostilbene alleviates cerebral ischemia and reperfusion injury in rats by modulating microglial activation. Food & function, 11(6), 5432-5445.
  9. ↑ McCormack, D., & McFadden, D. (2013). A review of pterostilbene antioxidant activity and disease modification. Oxidative medicine and cellular longevity, 2013.
  10. ↑ Gómez-Zorita, S., Milton-Laskíbar, I., Aguirre, L., Fernández-Quintela, A., Xiao, J., & Portillo, M. P. (2020). Effects of pterostilbene on diabetes, liver steatosis and serum lipids. Current medicinal chemistry, Volume 28, Number 2, 2021, pp. 238-252(15)
  11. ↑ Gómez-Zorita, S., Fernández-Quintela, A., Aguirre, L., Macarulla, M. T., Rimando, A. M., & Portillo, M. P. (2015). Pterostilbene improves glycaemic control in rats fed an obesogenic diet: involvement of skeletal muscle and liver. Food & function, 6(6), 1968-1976.
  12. ↑ Gomez-Zorita, S., Fernandez-Quintela, A., Lasa, A., Aguirre, L., Rimando, A. M., & Portillo, M. P. (2014). Pterostilbene, a dimethyl ether derivative of resveratrol, reduces fat accumulation in rats fed an obesogenic diet. Journal of agricultural and food chemistry, 62(33), 8371-8378.
  13. ↑ McCormack, D., & McFadden, D. (2012). Pterostilbene and cancer: current review. Journal of Surgical Research, 173(2), e53-e61.
  14. ↑ Younas, M., Hano, C., Giglioli-Guivarc'h, N., & Abbasi, B. H. (2018). Mechanistic evaluation of phytochemicals in breast cancer remedy: current understanding and future perspectives. RSC advances, 8(52), 29714-29744.
  15. ↑ Roca, P., Sastre-Serra, J., Nadal-Serrano, M., Pons, D. G., del Mar Blanquer-Rossello, M., & Oliver, J. (2014). Phytoestrogens and mitochondrial biogenesis in breast cancer. Influence of estrogen receptors ratio. Current pharmaceutical design, 20(35), 5594-5618.
  16. ↑ Jerzak, K. J., Duska, L., & MacKay, H. J. (2019). Endocrine therapy in endometrial cancer: An old dog with new tricks. Gynecologic oncology, 153(1), 175-183.
  17. ↑ Zheng, J., Liu, W., Zhu, X., Ran, L., Lang, H., Yi, L., ... & Zhu, J. (2020). Pterostilbene enhances endurance capacity via promoting skeletal muscle adaptations to exercise training in rats. Molecules, 25(1), 186.
  • Azzolini, M., La Spina, M., Mattarei, A., Paradisi, C., Zoratti, M., & Biasutto, L. (2014). Pharmacokinetics and tissue distribution of pterostilbene in the rat. Molecular nutrition & food research, 58(11), 2122-2132.
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