Cinnamaldéhyde

De WikiPhyto

Nom de la substance

Cinnamaldéhyde = aldéhyde cinnamique = trans-cinnamaldéhyde

Famille moléculaire

Source végétale

Propriétés

  • Anti-infectieux majeur à très large spectre d’action, forte activité antibactérienne vis-à-vis de Staphylococcus aureus, Escherichia coli, Enterobacter aerogenes, Proteus vulgaris, Pseudomonas aeruginosa, Vibrio cholerae, Vibrio parahaemolyticus, Samonella typhymurium, Micrococcus sp., Bacillus sp. et Enterobacter sp, même Helicobacter pylori, Mycobacterium avium, et antifongique vis-à-vis de Candida albicans, C. tropicalis, C. glabrata, C. krusei, Aspergillus spp, Fusarium sp. Microsporum gypseum, Trichophyton rubrum, T. mentagraphytes, Malassezia furfur [1], [2], [3], [4], [5]
  • Le mécanisme d'action antibactérien pourrait être une modulation de l'absorption et de l'utilisation du glucose dans la cellule et une action membranaire [6]
  • L'activité antifongique pourrait être une inhibition de synthèse des béta-glucanes et de la chitine [7]
  • Entre en synergie avec les phénols [8], [9], cinnamaldéhyde, acide cinnamique, eugénol, carvacrol, thymol montrent un effet synergique en association avec les antibiotiques et inhibent les mécanismes de résistance antibactérienne [10]
  • Anti-inflammatoire [11], par inhibition de la voie du NF-κB [12]
  • Hypoglycémiant et hypolipidémiant [13]
  • Sédatif du système nerveux central et légèrement anesthésiant
  • Stimulant cardiaque et respiratoire
  • Antitumoral, inducteur d'apoptose [14], cytotoxique sur cellules cancéreuses humaines [15]
  • Immunomodulant [16]
  • Activité larvicide sur les larves de certains moustiques [17]

Effet thérapeutique

Effets indésirables

  • Causticité pour les muqueuses et la peau, risque d'irritation cutanéo-muqueuse [18]
  • Toxicité gastro-intestinale, gastralgies
  • Risque allergique [19], [20], [21], éviter en cas d'allergie à la cannelle ou au baume du Pérou
  • Dose journalière acceptable pour l'être humain 1,25 mg/kg, DL 50 de 4,16 g/kg chez le rat [22]

Bibliographie

  1. Linda S. M. Ooi, Yaolan Li, Sheung-Lau Kam, Hua Wang, Elaine Y. L. Wong, Vincent E. C. Ooi. Antimicrobial Activities of Cinnamon Oil and Cinnamaldehyde from the Chinese Medicinal Herb Cinnamomum cassia Blume. The American Journal of Chinese Medicine (AJCM), Volume: 34, Issue: 3(2006) pp. 511-522
  2. Shang-Tzen Chang, Pin-Fun Chen, Shan-Chwen Chang. Antibacterial activity of leaf essential oils and their constituents from Cinnamomum osmophloeum. Journal of Ethnopharmacology, Volume 77, Issue 1, September 2001, Pages 123-127
  3. Stella Y. Y. Wong, Irene R. Grant, Mendel Friedman, Christopher T. Elliott, Chen Situ. Antibacterial Activities of Naturally Occurring Compounds against Mycobacterium avium subsp. Paratuberculosis. Applied and Environmental Microbiology, Oct. 2008, Vol. 74, No. 19, p. 5986–5990
  4. Ferhout H, Bohatier J, Guillo, J, Chalchat JC. Antifungal Activity of Selected Essential Oils, Cinnamaldehyde and Carvacrol against Malassezia furfur and Candida albicans. Journal of Essential Oil Research, Vol. 11, no. 1, pp. 119-129. Jan-Feb 1999. [1]
  5. Moleyar V, Narasimham P. Antibacterial activity of essential oil components. Int J Food Microbiol. 1992 Aug;16(4):337-42. PMID 1457292
  6. Alexander O. Gill and Richard A. Holley. Mechanisms of Bactericidal Action of Cinnamaldehyde against Listeria monocytogenes and of Eugenol against L. monocytogenes and Lactobacillus sakei. Applied and Environmental Microbiology, October 2004, p. 5750-5755, Vol. 70, No. 10
  7. Kyu-Ho Bang, Dong-Won Lee, Hee-Moon Park, Young-Ha Rhee. Inhibition of Fungal Cell Wall Synthesizing Enzymes by trans-Cinnamaldehyde. Bioscience, Biotechnology, and Biochemistry, Vol. 64 (2000) , No. 5 pp.1061-1063
  8. Nicole Didry, Luc Dubreuil and Madeleine Pinkas. Activity of thymol, carvacrol, cinnamaldehyde and eugenol on oral bacteria. Pharmaceutica Acta Helvetiae, Volume 69, Issue 1, July 1994, Pages 25-28
  9. Pei RS, Zhou F, Ji BP, Xu J. Evaluation of combined antibacterial effects of eugenol, cinnamaldehyde, thymol, and carvacrol against E. coli with an improved method. J Food Sci. 2009 Sep;74(7):M379-83. doi: 10.1111/j.1750-3841.2009.01287.x. PMID 19895484
  10. Langeveld WT, Veldhuizen EJ, Burt SA. Synergy between essential oil components and antibiotics: a review. Crit Rev Microbiol. 2014 Feb;40(1):76-94. doi: 10.3109/1040841X.2013.763219. PMID 23445470
  11. Gunawardena D, Karunaweera N, Lee S, van Der Kooy F, Harman DG, Raju R, Bennett L, Gyengesi E, Sucher NJ, Münch G. Anti-inflammatory activity of cinnamon (C. zeylanicum and C. cassia) extracts - identification of E-cinnamaldehyde and o-methoxy cinnamaldehyde as the most potent bioactive compounds. Food Funct. 2015 Jan 28. PMID 25629927
  12. Muhammad JS, Zaidi SF, Shaharyar S, Refaat A, Usmanghani K, Saiki I, Sugiyama T. Anti-inflammatory Effect of Cinnamaldehyde in Helicobacter pylori Induced Gastric Inflammation. Biol Pharm Bull. 2015;38(1):109-15. doi: 10.1248/bpb.b14-00609. PMID 25744466
  13. Subash Babu P, Prabuseenivasan S, Ignacimuthu S. Cinnamaldehyde--a potential antidiabetic agent. Phytomedicine. 2007 Jan;14(1):15-22. PMID 17140783
  14. Hyeon Ka, Hee-Juhn Park, Hyun-Ju Jung, Jong-Won Choi, Kyu-Seok Cho, Joohun Ha, Kyung-Tae Lee. Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells. Cancerletters, Volume 196, Issue 2, Pages 143-152 (10 July 2003)
  15. Fang Shih-Hua, Rao Yerra Koteswara, Tzeng Yew-Min. Cytotoxic Effect of trans-Cinnamaldehyde from Cinnamomum osmophloeum Leaves on Human Cancer Cell Lines. International Journal of Applied Science and Engineering 2004. 2, 2: 136-147
  16. Seung Ho Lee, Sun Young Lee, Dong Ju Son, Heesoon Lee, Hwan Soo Yoo, Sukgil Song, Ki Wan Oh, Dong Cho Han, Byoung Mog Kwon, Jin Tae Hong. Inhibitory effect of 2′-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF-κB activation in RAW 264.7 cells. Biochemical Pharmacology, Volume 69, Issue 5, 1 March 2005, Pages 791-799 [2]
  17. Sen-Sung Cheng, Ju-Yun Liu, Kun-Hsien Tsai, Wei-June Chen, Shang-Tzen Chang. Chemical Composition and Mosquito Larvicidal Activity of Essential Oils from Leaves of Different Cinnamomum osmophloeum Provenances. Journal of Agricultural and Food Chemistry 2004 52 (14), pp 4395–4400
  18. Bickers D, Calow P, Greim H, Hanifin JM, Rogers AE, Saurat JH, Sipes IG, Smith RL, Tagami H. A toxicologic and dermatologic assessment of cinnamyl alcohol, cinnamaldehyde and cinnamic acid when used as fragrance ingredients. Food and chemical toxicology, 2005, vol. 43, no6, pp. 799-836
  19. Vimala A. Majeti, Raymond R. Suskind. Mechanism of cinnamaldehyde sensitization. Contact Dermatitis, Volume 3, Issue 1, pages 16–18, February 1977
  20. Weibel H. Hansen J. Andersen KE. Cross-sensitization patterns in guinea pigs between cinnamaldehyde, cinnamyl alcohol and cinnamic acid. Acta dermato-venereologica, 1989, vol. 69, no4, pp. 302-307
  21. J. P. Nater, M. C. J. M. De Jong, A. J. M. Baar, E. Bleumink. Contact urticarial skin responses to cinnamaldehyde. Contact Dermatitis, Volume 3, Issue 3, pages 151–154, June 1977
  22. Goetz P, Ghédira K. Phytothérapie anti-infectieuse, Ed. Springer, 2012
  • Didry N, Dubreuil L, Pinkas M. Activity of thymol, carvacrol, cinnamaldehyde and eugenol on oral bacteria. Pharm Acta Helv. 1994 Jul;69(1):25-8. PMID 7938073
  • Gulab N. Jham, Onkar D. Dhingra, Carolina M. Jardim, Vânia M. M. Valente. Identification of the major fungitoxic component of cinnamon bark oil. Fitopatologia Brasileira. TEXTE INTÉGRAL [3]