Béta-caryophyllène

De WikiPhyto
(Redirigé depuis Β-caryophyllène)

Nom de la substance

Béta-caryophyllène (trans-béta-caryophyllène)

Famille moléculaire

Source végétale

Propriétés

  • Anti-inflammatoire [1], [2], ne nécessite pas l'action de stimulation adrénergique, contrairement à l'action de l'alpha-pinène [3], et avec effet de cytoprotection gastrique [4]
  • Antispasmodique, anesthésiant local [5]
  • Anticolitique [6]
  • Antalgique [7], ligand pour les récepteurs cannabinoïdes de type 2 (CB2) [8]
  • Antitumoral
  • Antiviral vis-à-vis d'herpès virus (mais pas antibactérien)
  • Neuroprotecteur dans la sclérose en plaques [9]
  • Pourrait aider à réduire la consommation alcoolique [10]
  • Anxiolytique [11], sans effet sur les récepteurs aux benzodiazépines [12]
  • Anticonvulsivant [13]
  • Protège les cellules β pancréatiques, augmente la libération d'insuline, diminue le stress oxydatif et l’inflammation du tissu pancréatique des rats diabétiques [14],
  • Hépatoprotecteur [15]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. Fernandes ES, Passos GF, Medeiros R, da Cunha FM, Ferreira J, Campos MM, Pianowski LF, Calixto JB. Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea. Eur J Pharmacol. 2007 Aug 27;569(3):228-36. PMID 17559833
  2. Agarwal RB, Rangari VD. Phytochemical investigation and evaluation of anti-inflammatory and anti-arthritic activities of essential oil of Strobilanthus ixiocephala Benth. Indian J Exp Biol. 2003 Aug;41(8):890-4. PMID 15248491
  3. Martin S, Padilla E, Ocete MA, Galvez J, Jimenez J, Zarzuelo A. Anti-inflammatory activity of the essential oil of Bupleurum fruticescens. Planta Med. 1993 Dec;59(6):533-6. PMID 8302953 [1]
  4. Tambe Y, Tsujiuchi H, Honda G, Ikeshiro Y, Tanaka S. Gastric cytoprotection of the non-steroidal anti-inflammatory sesquiterpene, beta-caryophyllene. Planta Med. 1996 Oct;62(5):469-70. http://www.ncbi.nlm.nih.gov/pubmed/9005452
  5. Ghelardini C, Galeotti N, Di Cesare Mannelli L, Mazzanti G, Bartolini A. Local anaesthetic activity of beta-caryophyllene. Farmaco. 2001 May-Jul;56(5-7):387-9. PMID 11482764
  6. Cho JY, Chang HJ, Lee SK, Kim HJ, Hwang JK, Chun HS. Amelioration of dextran sulfate sodium-induced colitis in mice by oral administration of beta-caryophyllene, a sesquiterpene. Life Sci. 2007 Feb 13;80(10):932-9. http://www.ncbi.nlm.nih.gov/pubmed/17188718
  7. Paula-Freire LI, Andersen ML, Gama VS, Molska GR, Carlini EL. The oral administration of trans-caryophyllene attenuates acute and chronic pain in mice. Phytomedicine. 2014 Feb 15;21(3):356-62. doi: 10.1016/j.phymed.2013.08.006. PMID 24055516
  8. Klauke AL, Racz I, Pradier B, Markert A, Zimmer AM, Gertsch J, Zimmer A. The cannabinoid CB₂ receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain. Eur Neuropsychopharmacol. 2014 Apr;24(4):608-20. doi: 10.1016/j.euroneuro.2013.10.008. PMID 24210682
  9. Alberti TB, Barbosa WL, Vieira JL, Raposo NR, Dutra RC. (-)-β-Caryophyllene, a CB2 Receptor-Selective Phytocannabinoid, Suppresses Motor Paralysis and Neuroinflammation in a Murine Model of Multiple Sclerosis. Int J Mol Sci. 2017 Apr 1;18(4). pii: E691. doi: 10.3390/ijms18040691. PMID 28368293
  10. Al Mansouri S, Ojha S, Al Maamari E, Al Ameri M, Nurulain SM, Bahi A. The cannabinoid receptor 2 agonist, β-caryophyllene, reduced voluntary alcohol intake and attenuated ethanol-induced place preference and sensitivity in mice. Pharmacol Biochem Behav. 2014 Sep;124:260-8. doi: 10.1016/j.pbb.2014.06.025. PMID 24999220
  11. Bahi A, Al Mansouri S, Al Memari E, Al Ameri M, Nurulain SM, Ojha S. β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice. Physiol Behav. 2014 Aug;135:119-24. doi: 10.1016/j.physbeh.2014.06.003. PMID 24930711
  12. Galdino PM, Nascimento MV, Florentino IF, Lino RC, Fajemiroye JO, Chaibub BA, de Paula JR, de Lima TC, Costa EA. The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, β-caryophyllene, in male mice. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Aug 7;38(2):276-84. doi: 10.1016/j.pnpbp.2012.04.012. PMID 22542869
  13. de Oliveira CC, de Oliveira CV, Grigoletto J, Ribeiro LR, Funck VR, Grauncke AC, de Souza TL, Souto NS, Furian AF, Menezes IR, Oliveira MS. Anticonvulsant activity of β-caryophyllene against pentylenetetrazol-induced seizures. Epilepsy Behav. 2016 Mar;56:26-31. doi: 10.1016/j.yebeh.2015.12.040. PMID 26827298
  14. Basha RH, Sankaranarayanan C. β-Caryophyllene, a natural sesquiterpene lactone attenuates hyperglycemia mediated oxidative and inflammatory stress in experimental diabetic rats. Chem Biol Interact. 2016 Feb 5;245:50-8. doi: 10.1016/j.cbi.2015.12.019. PMID 26748309
  15. Cho HI, Hong JM, Choi JW, Choi HS, Kwak JH, Lee DU, Kook Lee S, Lee SM. β-Caryophyllene alleviates D-galactosamine and lipopolysaccharide-induced hepatic injury through suppression of the TLR4 and RAGE signaling pathways. Eur J Pharmacol. 2015 Oct 5;764:613-21. doi: 10.1016/j.ejphar.2015.08.001. PMID 26254779
  • Sensch O, Vierling W, Brandt W, Reiter M. Effects of inhibition of calcium and potassium currents in guinea-pig cardiac contraction: comparison of beta-caryophyllene oxide, eugenol, and nifedipine. Br J Pharmacol. 2000 Nov;131(6):1089-96. PMID 11082115
  • Medeiros R, Passos GF, Vitor CE, Koepp J, Mazzuco TL, Pianowski LF, Campos MM, Calixto JB. Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw. Br J Pharmacol. 2007 Apr 30.
  • Sylvestre M, Legault J, Dufour D, Pichette A. Chemical composition and anticancer activity of leaf essential oil of Myrica gale L. Phytomedicine. 2005 Apr;12(4):299-304.