Béta-caryophyllène

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(Redirigé depuis Bêta-caryophyllène)

Nom de la substance

Béta-caryophyllène (trans-béta-caryophyllène)

Famille moléculaire

Source végétale

Propriétés

  • Anti-inflammatoire [1], [2], ne nécessite pas l'action de stimulation adrénergique, contrairement à l'action de l'alpha-pinène [3], et avec effet de cytoprotection gastrique [4]
  • Antispasmodique, anesthésiant local [5]
  • Anticolitique [6]
  • Ligand pour les récepteurs cannabinoïdes de type 2 (CB2)
  • Anesthésiant local
  • Antitumoral
  • Antiviral vis-à-vis d'herpès virus (mais pas antibactérien)

Effet thérapeutique

Effets indésirables

Bibliographie

  1. Fernandes ES, Passos GF, Medeiros R, da Cunha FM, Ferreira J, Campos MM, Pianowski LF, Calixto JB. Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea. Eur J Pharmacol. 2007 Aug 27;569(3):228-36. PMID 17559833
  2. Agarwal RB, Rangari VD. Phytochemical investigation and evaluation of anti-inflammatory and anti-arthritic activities of essential oil of Strobilanthus ixiocephala Benth. Indian J Exp Biol. 2003 Aug;41(8):890-4. PMID 15248491
  3. Martin S, Padilla E, Ocete MA, Galvez J, Jimenez J, Zarzuelo A. Anti-inflammatory activity of the essential oil of Bupleurum fruticescens. Planta Med. 1993 Dec;59(6):533-6. PMID 8302953 [1]
  4. Tambe Y, Tsujiuchi H, Honda G, Ikeshiro Y, Tanaka S. Gastric cytoprotection of the non-steroidal anti-inflammatory sesquiterpene, beta-caryophyllene. Planta Med. 1996 Oct;62(5):469-70. http://www.ncbi.nlm.nih.gov/pubmed/9005452
  5. Ghelardini C, Galeotti N, Di Cesare Mannelli L, Mazzanti G, Bartolini A. Local anaesthetic activity of beta-caryophyllene. Farmaco. 2001 May-Jul;56(5-7):387-9. PMID 11482764
  6. Cho JY, Chang HJ, Lee SK, Kim HJ, Hwang JK, Chun HS. Amelioration of dextran sulfate sodium-induced colitis in mice by oral administration of beta-caryophyllene, a sesquiterpene. Life Sci. 2007 Feb 13;80(10):932-9. http://www.ncbi.nlm.nih.gov/pubmed/17188718
  • Sensch O, Vierling W, Brandt W, Reiter M. Effects of inhibition of calcium and potassium currents in guinea-pig cardiac contraction: comparison of beta-caryophyllene oxide, eugenol, and nifedipine. Br J Pharmacol. 2000 Nov;131(6):1089-96. PMID 11082115
  • Medeiros R, Passos GF, Vitor CE, Koepp J, Mazzuco TL, Pianowski LF, Campos MM, Calixto JB. Effect of two active compounds obtained from the essential oil of Cordia verbenacea on the acute inflammatory responses elicited by LPS in the rat paw. Br J Pharmacol. 2007 Apr 30.
  • Sylvestre M, Legault J, Dufour D, Pichette A. Chemical composition and anticancer activity of leaf essential oil of Myrica gale L. Phytomedicine. 2005 Apr;12(4):299-304.