Rutoside

De WikiPhyto

Nom de la substance

rutoside = rutine (vient de sa présence dans la rue officinale = 3-O-rutinosylquercétol (= diglycoside du quercétol) = quercétol-3-rhamnoglucoside

  • théoriquement on réserve le terme en ine aux alcaloïdes)

Famille moléculaire

Flavonoïde (flavonol)

Source végétale

Propriétés

  • Propriétés circulatoires et protectrices vasculaires
  • Hydrolysé en quercétol dans le tractus gastro-intestinal
  • Anti-oxydant [1], anti-radicaux libres [2]
  • Anti-inflammatoire [3], [4]
  • Anticancer (colon) [5], [6]
  • Hépatoprotecteur [7]
  • Diminue la toxicité intestinale du méthotrexate [8]
  • Anti-ulcéreux par action sur la pompe à protons [9]
  • Protection anti-oxydante vis-à-vis d'un régime riche en cholestérol [10]
  • Prévention de l'oxydation des LDL [11]
  • Néphroprotecteur [12]
  • L'orcinol ou 3,4-dihydroxytoluène, un de se métabolites, est anti-inflammatoire [13]

Effet thérapeutique

Effets indésirables

Bibliographie

  1. Jianxiong Yang, Juan Guo, Jiangfeng Yuan. In vitro antioxidant properties of rutin. Lebensmittel - Wissenschaft + Technologie, 2008, vol. 41, no6, pp. 1060-1066 [1]
  2. Kandaswami C, Middleton E Jr.Free radical scavenging and antioxidant activity of plant flavonoids. Adv Exp Med Biol. 1994;366:351-76. PMID 7771265
  3. Guardia T, Rotelli AE, Juarez AO, Pelzer LE. Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Farmaco. 2001 Sep;56(9):683-7. PMID 11680812
  4. Rotelli AE, Guardia T, Juárez AO, de la Rocha NE, Pelzer LE. Comparative study of flavonoids in experimental models of inflammation. Pharmacol Res. 2003 Dec;48(6):601-6. PMID 14527825
  5. Deschner EE, Ruperto JF, Wong GY, Newmark HL. The effect of dietary quercetin and rutin on AOM-induced acute colonic epithelial abnormalities in mice fed a high-fat diet. Nutr Cancer. 1993;20(3):199-204. PMID 8108270
  6. Lin JP, Yang JS, Lu CC, Chiang JH, Wu CL, Lin JJ, Lin HL, Yang MD, Liu KC, Chiu TH, Chung JG. Rutin inhibits the proliferation of murine leukemia WEHI-3 cells in vivo and promotes immune response in vivo. Leuk Res. 2009 Jun;33(6):823-8. PMID 19010542
  7. Khan RA, Khan MR, Sahreen S. CCl4-induced hepatotoxicity: protective effect of rutin on p53, CYP2E1 and the antioxidative status in rat. BMC Complementary and Alternative Medicine 2012, 12:178 (8 October 2012) Abstract Provisional PDF
  8. Gautam R, Singh M, Gautam S, Rawat J, Saraf SA, Kaithwas G. Rutin attenuates intestinal toxicity induced by Methotrexate linked with anti-oxidative and anti-inflammatory effects. BMC Complementary and Alternative Medicine 2016, 16:99 (10 March 2016) Abstract texte intégral
  9. Shagun Dubey, Aditya Ganeshpurkar, Abhishek Shrivastava, Divya Bansal, and Nazneen Dubey. Rutin exerts antiulcer effect by inhibiting the gastric proton pump. Indian J Pharmacol. 2013 Jul-Aug; 45(4): 415–417. doi: 10.4103/0253-7613.115011 PMCID: PMC3757621 texte intégral
  10. Al-Rejaie SS, Aleisa AM, Sayed-Ahmed MM, AL-Shabanah OA, Abuohashish HM, Ahmed MM, Al-Hosaini KA, Hafez MM. Protective effect of rutin on the antioxidant genes expression in hypercholestrolemic male Westar rat. BMC Complementary and Alternative Medicine 2013, 13:136 (17 June 2013) Abstract Provisional PDF
  11. Anne Schmitt, Robert Salvayre, Jean Delchambre, Anne Negre-Salvayre. Prevention by a-tocopherol and rutin of glutathione and ATP depletion induced by oxidized LDL in cultured endothelial cells. British Journal of Pharmacology (1995) 116, 1985-1990 texte intégral
  12. Khan RA, Khan MR, Sahreen S. Protective effects of rutin against potassium bromate induced nephrotoxicity in rats. BMC Complementary and Alternative Medicine 2012, 12:204 (1 November 2012) Abstract, Provisional PDF
  13. Su K, Yu C, Chen Y, Hua K, Chen . 3,4-Dihydroxytoluene, a metabolite of rutin, inhibits inflammatory responses in lipopolysaccharide-activated macrophages by reducing the activation of NF-kappaB signaling. BMC Complementary and Alternative Medicine 2014, 14:21 (13 January 2014) Abstracttexte intégral