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Nom de la substance

Lutéoline, tétra-hydroxy 3',4',5,7 flavone

Famille moléculaire

Flavonoïde (flavone)

Source végétale


Effet thérapeutique

  • Maladies inflammatoires chroniques de l'intestin (MICI) [12]

Effets indésirables


  1. Saebyeol Jang, Keith W. Kelley, Rodney W. Johnson. Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1. Proc Natl Acad Sci U S A. 2008 May 27; 105(21): 7534–7539. Texte intégral
  2. Hiroshi Ueda, Chikako Yamazaki, Masatoshi Yamazaki. Luteolin as an Anti-inflammatory and Anti-allergic Constituent of Perilla frutescens. Biological and Pharmaceutical Bulletin, Vol. 25 (2002) No. 9 P 1197-1202 [1]
  3. Dong, X.; Wang, Y.; Liu, T.; Wu, P.; Gao, J.; Xu, J.; Yang, B.; Hu, Y. Flavonoids as Vasorelaxant Agents: Synthesis, Biological Evaluation and Quantitative Structure Activities Relationship (QSAR) Studies. Molecules 2011, 16, 8257-8272.
  4. Ko WG, Kang TH, Lee SJ, Kim YC, Lee BH. Effects of luteolin on the inhibition of proliferation and induction of apoptosis in human myeloid leukaemia cells. Phytother Res. 2002 May;16(3):295-8. PMID 12164283
  5. Shin, Soon Young & Yong, Yeonjoong & Hong, Dae & Lee, Da & Lee, Da & Lee, Young. (2015). Identification of flavonoids from Eriodictyon californicum and their cytotoxicity against HCT116 colon cancer cells. Journal of the Korean Society for Applied Biological Chemistry. 58. 10.1007/s13765-015-0015-0.
  6. Bédard Valérie. Les propriétés anti-angiogéniques des flavonoïdes. Mémoire de maîtrise en chimie. Université du Québec à Montréal, avril 2008
  7. S. Abdalla, M. Abu Zarga, S. Sabri. Effects of the flavone luteolin, isolated from Colchicum richii, on guinea-pig isolated smooth muscle and heart and on blood pressure and blood flow. Phytotherapy Research, Volume 8, Issue 5, pages 265–270, August 1994
  8. Yu MC, Chen JH, Lai CY, Han CY, Ko WC. Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, displaced [(3)H]-rolipram from high-affinity rolipram binding sites and reversed xylazine/ketamine-induced anesthesia. Eur J Pharmacol. 2009 Oct 22. PMID 19853596
  9. Guerrero L, Castillo J, Quiñones M, Garcia-Vallvé S, Arola L, Pujadas G, Muguerza B. Inhibition of angiotensin-converting enzyme activity by flavonoids: structure-activity relationship studies. PLoS One. 2012;7(11):e49493. doi: 10.1371/journal.pone.0049493. PMID 23185345
  10. Eddouks Mohamed, Chattopadhyay Debprasad. Phytotherapy in the Management of Diabetes and Hypertension. Bentham Science Publishers, 2012. eISBN : 978-1-60805-014-7
  11. Emran TB, Rahman MA, Uddin MMN, et al. Molecular docking and inhibition studies on the interactions of Bacopa monnieri’s potent phytochemicals against pathogenic Staphylococcus aureus. DARU Journal of Pharmaceutical Sciences. 2015;23(1):26. doi:10.1186/s40199-015-0106-9. PMID 25884228
  12. Nishitani Y, Yamamoto K, Yoshida M, Azuma T, Kanazawa K, Hashimoto T, Mizuno M. Intestinal anti-inflammatory activity of luteolin: role of the aglycone in NF-κB inactivation in macrophages co-cultured with intestinal epithelial cells. Biofactors. 2013 Sep-Oct;39(5):522-33. doi: 10.1002/biof.1091. PMID 23460110